Gemcitabine (pronunciation: jem-SITE-a-been) is a nucleoside analog used as chemotherapy. It is marketed as Gemzar near Eli Lilly and Company. Pharmacology Chemically gemcitabine is a nucleoside analog in which the hydrogen atoms on the 2' carbon of deoxycytidine are replaced byfluorine atoms. As with fluorouracil and other analogues of pyrimidines, the triphosphate analogue of gemcitabine replaces anybody of the structure blocks of nucleic acids, in this turn out that in the event of cytidine, during DNA replication. The process arrests tumor extension, as but one additional nucleoside can be betrothed to the "out of order" nucleoside, resulting in apoptosis. Another end of gemcitabine is the enzyme ribonucleotide reductase (RNR). The diphosphate analogue binds to RNR active site and inactivates the enzyme irreversibly. Definitely RNR is uptight, the chamber cannot yield the deoxyribonucleotides required in the interest of DNA replication and put back in, and cubicle apoptosis is induced.<> - From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
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